Defining gut health: the ISAPP consensus

A scientific consensus examines what gut health means and how it can be described and measured. This is a field-wide definition, not a Totipro product trial.

Scientific consensus

SCI JOURNAL
2026

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health

Nat Rev Gastroenterol Hepatol
Marco ML, Cunningham M, Bischoff SC, Clarke G, Delzenne N...

The term 'gut health' is increasingly used as a catch-all phrase by many stakeholders, including scientists, health-care professionals, industry and the general public, to describe a wide range of health-related concepts. Despite its widespread use, particularly in relation to studies on diet, fermented foods, biotics and the gut microbiome, it remains unclear what the term gut health means. Therefore, an expert panel was convened by the International Scientific Association for Probiotics and Prebiotics to address the current state of scientific and clinical knowledge on the physiology, manifestation, application and measurement of the concept of gut health.

DOI: 10.1038/s41575-026-01176-x

How to use this research

A scientific consensus examines what gut health means and how it can be described and measured. This is a field-wide definition, not a Totipro product trial. Findings should be interpreted using the tested preparation, population and outcomes.

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